Common Side Effects

About Common Side Effects

Former high school lab partners Marshall and Frances begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.

Common Side Effects is an animation, comedy, and science fiction series that airs on Adult Swim. Since February 2025 it has reached 2 seasons and 10 episodes.

The series is filed under optimistic, government conspiracy, mushroom, and comedy thriller. Dave King leads the cast as Marshall Cuso (voice), Emily Pendergast as Frances Applewhite (voice), Mike Judge as Rick Kruger (voice), and Martha Kelly as Agent Harrington (voice).

Production companies include Bandera Entertainment, Green Street Pictures, and Tell Me More. It streams on Adult Swim, HBO Max, and HBO Max Amazon Channel in the United States.

Hazbin Hotel, Archer, and Designated Survivor make useful companions to Common Side Effects, all filed under adult animation, dark comedy, and conspiracy. TMDB voters put it at 8.5 out of 10 across 365 votes and it carries a TV-MA rating.